Blog of tashpeptide

TASH Biotechnology is specializing in peptide and peptide synthesis services. We offer a comprehensive selection of custom peptide synthesis services, peptide APIs (as active pharmaceutical ingredients).

We could provide

CJC1295,

CJC1295 DAC,

Melanotan-1,

Melanotan-2,

GHRP-2,

GHRP-6,

Sermorelin,

PT141,

HGH Frag(177-191),

Hexarelin,

Ipamorelin,

Argireline,

Matrixyl 3000,

Lipopeptide,

MGF

PEG-MGF.

Since we are manufacturer, we could quality and very competitive price.

If you are interested in any of them, please feel free to let me know.

Thanks and best regards,

Kevin Sun

TASH Biotechnology Co., td

Kevinsun(at)tashpeptide(dot)com

MSN: peptide2009(at)hotmail(dot)com

Googletalk: peptide2009(at)gmail.com

Skype: dellnent

Melanotan (MT) and Melanotan II (MT-II) are both analogs of the alpha-melanocyte stimulating hormone (?-MSH) which is produced within the pituitary gland. Along with other melanocortins, they are responsible for various internal human functions including skin and hair pigmentation, appetite, libido and physical sexual arousal. Whilst these effects have been observed in both sexes, it is worth noting that increases in libido and sexual function are exclusive to MT-II. This article will primarily look at the tanning and pigmentation properties of the hormone, though it would be foolish to ignore the other effects which are discussed further in the Side Effects section.Prompted by ultraviolet (UV) exposure, ?-MSH release consequently stimulates production of melanin from the melanocytes within the skin. Melanin, as I’m sure you are aware, is a brown pigment and responsible for the tanning of the skin. Simply put, more ?-MSH means more melanin, resulting in greater skin pigmentation. Since bodybuilding is such an aesthetic pursuit, and with darker skin that accentuates muscularity, it’s little wonder that these drugs are in such high demand.Currently, analogs based upon MT and MT-II are undergoing clinical trials, with a view to bringing medicinal products to market. These synthetic variants of ?-MSH were developed at the

University of
Arizona during the 1980s. Australian based Clinuvel Pharmaceuticals Limited have marketing rights to MT (CUV1647), with their primary market being individuals with adverse reaction to UV exposure. This includes those with Polymorphous Light eruption (PLE/PMLE) and Actinic Keratosis (AKs or solar keratosis) where skin is intolerant to UV and characterised by severe sores, lumps, itching or burning sensations, or dry skin lesions/growths. You might think that this peptide would be an ideal treatment for pure albinos. However, these individuals are generally not deficient in ?-MSH, but instead are have zero melanocyte receptor binding. Therefore, merely increasing circulatory levels of ?-MSH or its analogs is futile. Palatin Technologies Inc. based in the
United States, has instead focused on an analog of MT-II. Licensed as Bremelanotide (formerly PT-141), this is aimed squarely at the sexual dysfunction market, more specifically, erectile dysfunction (ED) in men. However, early (phase I & II) clinical trials have also been performed using female subjects with results being described by the company as ‘encouraging’.Both Melanotan and Melanotan II have been shown in the clinical setting to increase pigmentation without exposure to UV, a feature that is also confirmed anecdotally by users that report tanning in areas of the body that would seldom see the light of day! However, the process of tanning is greatly expedited by UV exposure. It is worth noting that tanning effects may not be uniform throughout the skin. This is in part due to the half life and distribution of the drug itself, but primarily in response to the concentration of melanocytes within certain areas of the skin. Most will notice the greatest tanning effect on the face, arms, abdominal region. Interestingly, the genitals have one of the highest concentrations of melanocytes enabling these particular areas to respond very well to the peptide in conjunction with UV exposure.As I’m sure you can appreciate, the development of these peptides has not gone unnoticed by the general population and as a result, there has been an explosion of suppliers looking to exploit such demand, with the peptides being formulated and originating largely from
China. Although not classed as controlled substances in the
UK, they are viewed as medicinal substances by the MHRA (Medicines and Healthcare products Regulatory Agency). While this means that you can legally possess them for personal use, sale or supply is dependant upon whether the product holds a Marketing Authorisation (product licence) valid for the
UK. Since I cannot find any evidence of this, nor would I expect to at this juncture of development, suppliers plying their trade within the
UK are doing so illegally.Suggested Cycles/Uses
If you look hard enough out there, you will find some weird and wonderful dosaging schedules whereby the user calculates their daily dosage by multiplying their bodyweight by a cofactor. Perhaps this approach has been adopted since this has been the method employed in the ongoing clinical studies. Typically, this type of formula would suggest a dose of 1mg of MT-II per day for someone weighing in at a mere 110lb (50kg). The cynical among us might be forgiven for thinking that these formulae are constructed by those with a personal interest in the sale of the product as I believe this to be more than necessary to achieve a great result. Indeed, there are many instances whereby users feel they have become too dark. While I have no problem with a bodyweight dosage scale in principle, I can’t help thinking that it’s not only unnecessary (particularly for the mathematically challenged), but also avoids the ability to gradually increase dosages from a relatively low level; something which I would advocate to assess individual tolerance levels to side effects, especially in the case of MT-II.Clinical trials to determine efficacy of the drugs have typically used dosages up to 0.21mg/kg daily for Melanotan (16mg for a 75kg (165lb) individual), and up to 0.03mg/kg daily for Melanotan II (2.25mg for a 75kg (165lb) individual). More typically however, trials have used the dosages of 0.16mg/kg (12mg) and 0.025mg/kg (1.875mg) respectively. At this level of dosage, one such study involving Melanotan indicated the following incidences of side effects from subjects:·     Nausea 85% ·     Facial
Flushing 75% ·     Fatigue 44% ·     Vomiting 26% ·     Injection site reactions 13% ·     Zero incidence of erections ·     No change in vital signs or haematological parameters, blood biochemistry (liver and renal function)As is the case with any drug use, the user is ideally looking to minimise unwanted side effects, whilst still achieving an acceptable outcome. With this in mind, I would suggest that a tapering up of dosages is used in order to assess the individual’s personal tolerance to the side effects.Both MT and MT II can be used for extended periods, whereby there is an initial daily administration of perhaps 2-3 weeks or until desired level of pigmentation has been achieved, followed by a maintenance phase of two injections per week.Melanotan:
Start with a dose of 1mg daily for the first two or three days and, if level of side effects permit, look to increase dosage by 0.25mg every day over the next several days until you reach a daily dosage of 2-3mg. This level should be adequate for most users, though some may wish to increase yet further, perhaps as high as 5mg daily in order to achieve a very deep tan. A maintenance phase as described above is then used.Melanotan II:
Start with a dose of 0.25mg. If side effects (primarily nausea) are not proving troublesome, attempt to increase daily dosage by 0.25mg where possible, until you reach 1-1.5mg daily. Most have found that this level will yield a very pleasing result and I can’t see much point in increasing too much further unless a very deep tan was desired. As with Melanotan, once the desired level of tanning is reached, a maintenance phase is used.Administration
Both MT and MT II are currently supplied as white lyophilised powder contained in a sealed multi-use vial. The peptide is susceptible to temperature degradation and should be shipped preferably with an ice pack though contrary to popular belief, the rate of degradation is very slow (weeks) in its powder form, so there’s no need to be alarmed if yours wasn’t shipped in this manner or you are unable to collect your package from a depot for a day or two. Once delivered, the powder is best stored in a freezer, or refrigerated if this is not possible.To prepare for injection, it must be reconstituted with bacteriostatic water. You may use anything between 1ml and 5ml of water for your vial. Dependant upon the amount of water used will determine the concentration of your solution. For example, a 10mg vial of Melanotan II mixed with 1ml of water will provide a solution of 10mg per 1ml (10mg/ml). This means that a 1mg dose will require a shot of 0.1ml. Bearing in mind that the recommended starting dose is 0.25mg, using the example above, the actual volume of the shot would be 0.025ml (¼ of 1 tenth of a ml). This is a very small volume and very difficult to accurately dose even with a 0.5ml insulin syringe. Therefore, at least until your dosages have increased, it is suggested that you use more water for your vial.An example of a good solution would be to mix 10mg of Melanotan II powder with 4ml of bacteriostatic water. This now provides:10mg/4ml or 1mg/0.4ml or 0.25mg/0.1ml0.1ml can be accurately measured using a 0.5ml or 1ml syringe.Obviously, as your dosages become higher, you may dilute subsequent vials with lower amounts of water to reduce the volume of each shot. I would recommend that when you are using a dosage of 1mg, you reconstitute the vial with 1ml or 2ml of water so that each shot will be 0.1ml or 0.2ml respectively.The injection is given into the sub-cutaneous layer which includes adipose tissue (fat), as in the figure below:If you are using insulin syringes which have short needles, you will need to enter the skin at 90°. to the skin, otherwise you can inject as shown in the illustration above with a 29 or 30 gauge, 0.5″ needle.I would suggest that you use standard 1ml syringes to which you can interchange needles as required. By doing so, you are able to attach any gauge/length you want to reconstitute and draw the solution (I use a 25guage 1″ needle). Once done, simply attach your suitable needle for the injection. Following the injection, ensure that you pull back the plunger a little to ‘reclaim’ the solution that is contained within the needle itself. The syringe/needle is then placed in the refridgerator for storage until your next injection is due whereby you will attach a brand new injection needle. This process is repeated until you have administered all of the solution in that particular syringe.Alternatively, you may pre-load insulin syringes and refrigerate until needed. However, because they have non-detachable needles, this can be quite cumbersome as they require loading from the rear.

Instability of the peptide is a much greater issue once reconstituted so you don’t want it sitting in the fridge for months on end. Ideally one 10mg vial of MT-II could be shared by two people (each having their own syringe/needles) so even during the maintenance phase of two injections per week of 1mg each; the longest it will be reconstituted for is 2.5 weeks

Kevin

MSN: PEPTIDE2009@HOTMAIL.COM

SKYPE: dellnent

PT141 is being touted as the first true aphrodisiac and the first drug since the availability of birth control pills 40 years ago that has the potential to spark another sexual revolution. It is now known by its generic name, Bremelanotide, which was originally developed from Melanotan II. Melanotan II was initially tested as a sunless tanning agent and was proven effective for inducing tanning, but it was also found to cause sexual arousal and spontaneous erections as unexpected side effects.
PT141 will undergo Phase III clinical studies in the second half of 2006 by Palatin Technologies, Inc. When the studies are completed, Palatin plans to submit an NDA to the FDA for approval to market PT141 in the
United States in 2007. PT141 belongs to a new class of drugs called melanocortin agonists used to treat sexual dysfunction. As a result of previous studies, PT141 has proven to be promising for the treatment of both male and female sexual dysfunction. While male sexual enhancers such as Viagra, Levitra and Cialis have been on the market for years, women have been left out in the cold, so to speak, when it comes to treating sexual dysfunction. Studies on female rats conducted by Palatin Technologies, the company developing the drug, in conjunction with
Concordia
University in
Montreal, have found that PT141 reportedly increased sexual activity in female rats. PT141 was found to encourage the female rats to seek out males rats for sex. In studies with men, PT141 was shown to improved erectile dysfunction without the cardiovascular effects found in erectile dysfunction drugs currently on the market. Results of the studies were as follows:·         Approximately 70% of patients considered PT141 to be as or more effective than Viagra ·         The quality of erection with PT141 was perceived to be as good or better than Viagra in 83% of patients ·         Safe and effective even at low doses ·         Faster onset than Viagra and lasts longer than Viagra ·         PT141 is an odorless, colorless chemical that is administered through a nasal spray. Unlike acting directly on the vascular system (blood flow to the penis) like sexual dysfunction drugs currently available, PT141 (Bremelanotide) acts directly on the central nervous system. PT141 is a copy of the hormone that stimulates the melanocyte receptors in the brain that trigger sexual arousal. PT141 may be effective in treating both the desire as well as the physical arousal problems of sexual dysfunction. This is what make PT141 a promising and potentially powerful sexual enhancement drug for both men and women. Cord Blodd and chantex smoking.

Some of the new drugs in 2008 includes ventolin for alergy, Acomplia, capromorelin and famvir,

Kevin

MSN: peptide2009@hotmail.com

Skype: dellnent

Bremelanotide (formerly PT-141) is a compound under drug development by Palatin Technologies as a treatment for hemorrhagic shock and reperfusion injury. It functions by activating the melanocortin receptors MC1R and MC4R, to modulate inflammation and limiting ischemia. It was originally developed for use in treating sexual dysfunction but this application was discontinued in 2008, after concerns were raised over adverse side effects of increased blood pressure. 

Today, the makers of PT141, a nasal spray which acts as an aphrodisiac are receiving a large amount of press coverage. Seems like everyone is finally catching up with the small
New Jersey companies findings concerning PT141.The precise mechanisms by which PT-141 does its job remain unclear, but the rough idea is this … where Viagra acts on the circulatory system, helping blood flow into the penis, PT-141 goes to the brain itself. It’s not merely allowing a sexual response to take place more easily, it’s having an effect, literally, on how a person thinks and feels. It’s been found to even improve the female sex drive.Talk about better living through chemistry!Palatin Technologies, the New Jersey-based maker of PT-141, has hopes of its own. Once the company gets Food and Drug Administration (FDA) approval for the drug, Palatin plans to market it to the same people targeted by Viagra: male erectile dysfunction patients.Help For WomenIn the wake of Pfizer’s failed attempts to prove Viagra works for women and amid growing recognition that it also doesn’t work for large numbers of men, these two markets alone could make PT-141 a pharmaceutical blockbuster. Approval for PT141 as a treatment for female sexual dysfunction may follow.Say hello to the real, first female viagra.In the Mood For LovePT141 finds itself in an awckward position however… a drug that makes you not only able but eager and willing isn’t going to remain the exclusive property of the severely impaired. As with Viagra, there will be extensive off-label use of PT-141. Fast-acting and long-lasting, packaged in an easily concealed, single-use nasal inhaler, unaffected by food or alcohol consumption, PT-141 seems bound to take its place alongside cocaine, poppers and alcohol in the pantheon of club drugs.Love Potion #9While considering the possibilities of PT141 not only improving your sexual performance but also increasing your sex drive has astounding implications.Could we soon see the effects of love and lust replaced by a nasal spray so commonly seen at the height of allergy season? Will PT141 replace the birds and the bee’s and the effect’s of good old Mother Nature?For literally millions of couples … PT141 could be a blessing for lagging sex life and decreased libido’s on both sides of the bed.

On the other hand … PT141, also known as the “Barbie Drug” is just the type of sexual help innovation ripe for abuse by a general public bent on sexual excesses.

Kevin

MSN: peptide2009@hotmail.com

Skype: dellnent

Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, a Long-acting Analogue of Growth Hormone-Releasing Hormone, in Healthy Adults
Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, and Lawrence A. Frohman*

Conclusions: sc administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-1 levels in healthy adults and was safe and relatively well-tolerated, particularly at doses of 30 µg/kg or 60 µg/kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.

Another readers digest version. This study is fairly relevant as it was done on men 20-40 years old. It also gives the dosage per kg of body weight used.

Conclusions: CJC-1295 increased trough and mean GH secretion and IGF-1 production with preserved GH pulsatility. The marked enhancement of trough GH levels by continuous GHRH stimulation implicates the importance of this effect on increasing IGF-1. Long-acting GHRH preparations may have clinical utility in patients with intact pituitary GH secretory capability.

Kevin

MSN: peptide2009@hotmail.com

Skype: dellnent

Reduces the most stubborn abdominal fat.
- Increases muscle mass.
- Increases IGF-1 levels, in an effective manner, thus making this a peptide that burns fat and exhibits anabolic function.
- Increases energy expenditure.
- Improves lipid profiles and lipolytic activity.
- Does not negatively impact blood glucose level, nor does cell proliferation occur, like Human Growth Hormone.
- Extremely potent and effective fat burner.

RESEARCH DOSAGE:
- 500mcg-2mg every day

Kevin

MSN: peptide2009@hotmail.com

Skype: dellnent

CJC-1293 or modified GRF(1-29) is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2,8,15,and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, at position 8 to reduce asparagine rearrangement or amdie hydrolysis to aspartic acid, position 15 to enhance bio-activity, and position 27 to prevent methionine oxidation.

CJC1293 is a short acting secretogoge, It is often falsley sold as CJC 1295. Unless you have a good source and buy CJC 1295 you are most likely getting CJC1293 which is the reason many people dose their CJC1295 daily just to be safe. because it is easier to make and is cheaper. has to be injected daily.

CJC 1295:
DAC conjugated CJC 1295 (Receptor Grade) is an hGH secretogue that is unique by way of an additional lysine molecule that is added to facilitate the DAC complex. This conjugation makes for a much longer half-life. DAC CJC 1295 tends to have a very limited availability everywhere due to expense and difficulty to manufacture. CJC 1295 DAC is a exceptionally designed peptide and is known for being the finest of the hGH secretogues

Kevin

MSN: peptide2009@hotmail.com

Skype: dellnent

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